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- Gaetano Santulli
- The Wu Center for Molecular Cardiology Columbia University New York NY USA
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- Ryutaro Nakashima
- The Wu Center for Molecular Cardiology Columbia University New York NY USA
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- Qi Yuan
- The Wu Center for Molecular Cardiology Columbia University New York NY USA
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- Andrew R. Marks
- The Wu Center for Molecular Cardiology Columbia University New York NY USA
説明
<jats:title>Abstract</jats:title><jats:p>Ryanodine receptors (RyRs) and inositol 1,4,5‐trisphosphate receptors (IP<jats:sub>3</jats:sub>Rs) are calcium (Ca<jats:sup>2+</jats:sup>) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca<jats:sup>2+</jats:sup> release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus. <jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/png" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/tjp12337-gra-0001-m.png"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text> </jats:p>
収録刊行物
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- The Journal of Physiology
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The Journal of Physiology 595 (10), 3041-3051, 2017-05-15
Wiley
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詳細情報 詳細情報について
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- CRID
- 1361699996470242560
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- DOI
- 10.1113/jp272781
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- ISSN
- 14697793
- 00223751
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- データソース種別
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- Crossref