Postoperative Cataract Cases among Atomic Bomb Survivors: Radiation Dose Response and Threshold
書誌事項
- 公開日
- 2007-10
- DOI
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- 10.1667/rr0928.1
- 公開者
- Radiation Research Society
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説明
Recent evidence argues against a high threshold dose for vision-impairing radiation-induced cataractogenesis. We conducted logistic regression analysis to estimate the dose response and used a likelihood profile procedure to determine the best-fitting threshold model among 3761 A-bomb survivors who underwent medical examinations during 2000-2002 for whom radiation dose estimates were available, including 479 postoperative cataract cases. The analyses indicated a statistically significant dose-response increase in the prevalence of postoperative cataracts [odds ratio (OR), 1.39; 95% confidence interval (CI), 1.24-1.55] at 1 Gy, with no indication of upward curvature in the dose response. The dose response was suggestive when the restricted dose range of 0 to 1 Gy was examined. A nonsignificant dose threshold of 0.1 Gy (95% CI,0-0.8) was found. The prevalence of postoperative cataracts in A-bomb survivors increased significantly with A-bomb radiation dose. The estimate (0.1 Gy) and upper bound (0.8 Gy) of the dose threshold for operative cataract prevalence was much lower than the threshold of 2-5 Gy usually assumed by the radiation protection community and was statistically compatible with no threshold at all.
収録刊行物
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- Radiation Research
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Radiation Research 168 (4), 404-408, 2007-10
Radiation Research Society
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詳細情報 詳細情報について
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- CRID
- 1361981468615199488
-
- DOI
- 10.1667/rr0928.1
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- ISSN
- 19385404
- 00337587
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- PubMed
- 17903036
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- データソース種別
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- Crossref
- OpenAIRE
