Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism

Wei Yang, Yang Gao

doi:10.1146/annurev-biochem-062917-012405

Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism

DOI Web Site 被引用文献4件

Wei Yang

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA;
Yang Gao

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA;

書誌事項

公開日: 2018-06-20

DOI

10.1146/annurev-biochem-062917-012405

公開者: Annual Reviews

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説明

<jats:p> The number of DNA polymerases identified in each organism has mushroomed in the past two decades. Most newly found DNA polymerases specialize in translesion synthesis and DNA repair instead of replication. Although intrinsic error rates are higher for translesion and repair polymerases than for replicative polymerases, the specialized polymerases increase genome stability and reduce tumorigenesis. Reflecting the numerous types of DNA lesions and variations of broken DNA ends, translesion and repair polymerases differ in structure, mechanism, and function. Here, we review the unique and general features of polymerases specialized in lesion bypass, as well as in gap-filling and end-joining synthesis. </jats:p>