Efficacy of oral supplemental hydration for the prevention of contrast-induced nephropathy in rats
書誌事項
- 公開日
- 2017-02-15
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1007/s11604-017-0620-4
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
To compare oral rehydration solution (ORS) with saline infusion for preventing contrast-induced nephropathy (CIN) in a rat model.Adult male Sprague-Dawley rats (310-360 g) received intravenous indomethacin (10 mg/kg), NHydration with saline prevented only the contrast-induced increase in plasma creatinine, whereas ORS prevented deleterious changes in plasma creatinine, blood urea nitrogen, and creatinine clearance as well as in urinary protein, albumin, and N-acetyl-D-glucosaminidase concentrations. Histopathologic changes noted in the CIN group were diminished in both saline and ORS groups.Both intravenous saline administration and oral hydration with ORS decreased the severity of CIN. Hydration with ORS was comparable to intravenous saline infusion in preventing CIN-associated abnormalities.
収録刊行物
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- Japanese Journal of Radiology
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Japanese Journal of Radiology 35 (4), 190-196, 2017-02-15
Springer Science and Business Media LLC
