Lack of CD27−CD45RA−Vγ9Vδ2+ T Cell Effectors in Immunocompromised Hosts and During Active Pulmonary Tuberculosis

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  • Cristiana Gioia
    Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,
  • Chiara Agrati
    Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,
  • Rita Casetti
    Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,
  • Cristiana Cairo
    Research Center, “San Pietro-Fatebenefratelli” , Rome ,
  • Giovanna Borsellino
    Laboratory of Neuroimmunology, “Santa Lucia Foundation,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,
  • Luca Battistini
    Laboratory of Neuroimmunology, “Santa Lucia Foundation,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,
  • Giorgio Mancino
    Research Center, “San Pietro-Fatebenefratelli” , Rome ,
  • Delia Goletti
    Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,
  • Vittorio Colizzi
    Department of Biology, University of Rome, “Tor Vergata” , Rome ,
  • Leopoldo P Pucillo
    Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,
  • Fabrizio Poccia
    Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,

書誌事項

公開日
2002-02-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.168.3.1484
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>In humans, the circulating pool of mycobacteria-reactive Vγ9Vδ2+ T cells is expanded with age and may contribute to Mycobacterium tuberculosis immunosurveillance. We observed that two subsets of Vγ9Vδ2+ T cells could be identified on the basis of CD27 expression in immunocompetent adults, showing that functionally differentiated γδ T cells have lost CD27 expression. In contrast, the CD27−CD45RA−Vγ9Vδ2+ T cell subset of effector cells was absent in cord blood cells from healthy newborns and lacking in the peripheral blood from HIV-infected patients. Moreover, circulating Vγ9Vδ2+ T cell effectors were significantly reduced in patients with acute pulmonary tuberculosis, resulting in a reduced frequency of IFN-γ-producing cells after stimulation with nonpeptidic mycobacterial ligands. These observations indicate that monitoring and boosting γδ T cell effectors could be clinically relevant both in immunocompromised hosts and during active tuberculosis disease.</jats:p>

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