General and practical catalytic enantioselective Strecker reaction of ketoimines: significant improvement through catalyst tuning by protic additives
書誌事項
- 公開日
- 2004-04
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
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- 10.1016/j.tetlet.2004.02.082
- 公開者
- Elsevier BV
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説明
Abstract Significant improvement in enantioselectivity and catalyst activity was achieved for the catalytic enantioselective Strecker reaction. Using a catalyst (1–2.5 mol %) prepared from Gd(O i Pr) 3 and d -glucose derived ligand 1 , and in the presence of 2,6-dimethylphenol as an additive, high enantioselectivity was obtained from a wide range of ketoimines, including heteroaromatic and cyclic ketoimines. The new method was applied to an efficient catalytic asymmetric synthesis of sorbinil, a therapeutic agent for diabetic complications.
収録刊行物
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- Tetrahedron Letters
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Tetrahedron Letters 45 (15), 3147-3151, 2004-04
Elsevier BV