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- Rossella Venditti
- Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, Naples 80131, Italy.
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- Tiziana Scanu
- Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
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- Michele Santoro
- Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, Naples 80131, Italy.
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- Giuseppe Di Tullio
- Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
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- Alexander Spaar
- Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
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- Renato Gaibisso
- Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
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- Galina V. Beznoussenko
- Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
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- Alexander A. Mironov
- Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
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- Alexander Mironov
- Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
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- Leopoldo Zelante
- Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Foggia, Italy.
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- Maria Rosaria Piemontese
- Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Foggia, Italy.
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- Angelo Notarangelo
- Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Foggia, Italy.
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- Vivek Malhotra
- Department of Cell and Developmental Biology, Centre de Regulacio Genomica, 08010 Barcelona, Spain.
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- Barbara M. Vertel
- Department of Cell Biology and Anatomy, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
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- Cathal Wilson
- Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, Naples 80131, Italy.
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- Maria Antonietta De Matteis
- Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, Naples 80131, Italy.
説明
<jats:title>A Tight Squeeze</jats:title> <jats:p> During intracellular transport, the export of procollagen from the endoplasmic reticulum is intriguing because procollagen is too large to fit into conventional coat protein complex II (COPII)–coated transport vesicles. Recent work has implicated the receptor TANGO1 in procollagen export. Now, <jats:bold> Venditti <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1668" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1224947">1668</jats:related-article> ) report that TANGO1 recruits Sedlin—also known as TRAPPC2, a homolog of the yeast TRAPP subunit Trs20—and helps to allow COPII-coated carriers to grow large enough to incorporate procollagen. </jats:p>
収録刊行物
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- Science
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Science 337 (6102), 1668-1672, 2012-09-28
American Association for the Advancement of Science (AAAS)