γ-Glutamyltransferase as a Predictor of Chronic Kidney Disease in Nonhypertensive and Nondiabetic Korean Men

DOI PDF 被引用文献12件
  • Seungho Ryu
    Department of Occupational Medicine and Health Screening Center,
  • Yoosoo Chang
    Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine. Seoul, Korea
  • Dong-Il Kim
    Department of Occupational Medicine and Health Screening Center,
  • Won Sool Kim
    Department of Occupational Medicine and Health Screening Center,
  • Byung-Seong Suh
    Department of Occupational Medicine and Health Screening Center,

書誌事項

公開日
2007-01-01
権利情報
  • https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
DOI
  • 10.1373/clinchem.2006.078980
公開者
Oxford University Press (OUP)

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説明

<jats:title>Abstract</jats:title><jats:p>Background: Little research has been done to examine whether γ-glutamyltransferase (GGT) is prospectively associated with the development of chronic kidney disease (CKD). We performed a prospective study to examine the association between GGT and the risk for the development of CKD.</jats:p><jats:p>Methods: The study cohort included a total of 10 337 healthy males with normal baseline kidney functions and no proteinuria. Participants were workers in a semiconductor manufacturing company and its 13 affiliates. CKD was defined as either the presence of proteinuria or a glomerular filtration rate (GFR) of &lt;60 mL · min−1 · (1.732)−1. Cox proportional hazards models were used to calculate the adjusted hazard ratios in separate models for CKD.</jats:p><jats:p>Results: During a follow-up period of 25 774.4 person-years, 366 men developed CKD. After adjustments were made for age, baseline GFR, triglyceride, and HDL-C, the risk for CKD increased with an increasing quartile of serum GGT (p for trend &lt;0.001). The top one fourth of serum GGT vs the bottom one fourth of relative risks for CKD was 1.90 (95% confidence interval, 1.37–2.63). These associations were also apparent in participants who consumed ≤20 g/day of alcohol and those with normal weight, with values of alanine aminotransferase within reference intervals, or with C-reactive protein &lt;3.0 mg/L, and participants without metabolic syndrome.</jats:p><jats:p>Conclusions: Our findings, which were obtained from a large work-site cohort and excluded individuals with diabetes and hypertension, indicated that serum GGT may be an early predictor for the development of CKD, independent of baseline confounding factors.</jats:p>

収録刊行物

  • Clinical Chemistry

    Clinical Chemistry 53 (1), 71-77, 2007-01-01

    Oxford University Press (OUP)

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