<i>Aggregatibacter actinomycetemcomitans</i> –induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis
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- Maximilian F. Konig
- Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
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- Loreto Abusleme
- National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
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- Jesper Reinholdt
- Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
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- Robert J. Palmer
- National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
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- Ricardo P. Teles
- Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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- Kevon Sampson
- Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
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- Antony Rosen
- Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
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- Peter A. Nigrovic
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA 02115, USA.
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- Jeremy Sokolove
- Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
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- Jon T. Giles
- Division of Rheumatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
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- Niki M. Moutsopoulos
- National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
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- Felipe Andrade
- Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
抄録
<jats:p> <jats:italic>Aggregatibacter actinomycetemcomitans</jats:italic> generates citrullinated autoantigens involved in rheumatoid arthritis through its pore-forming toxin leukotoxin A. </jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 8 (369), 369ra176-, 2016-12-14
American Association for the Advancement of Science (AAAS)