Expression of Cre recombinase in the developing mouse limb bud driven by a <i>Prxl</i> enhancer
書誌事項
- 公開日
- 2002-05-08
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/gene.10092
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Summary: We have used a <jats:italic>Prx1</jats:italic> limb enhancer to drive expression of Cre Recombinase in transgenic mice. This regulatory element leads to Cre expression throughout the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. Crossing a murine line carrying this transgene to a reporter mouse harboring a floxed Cre‐reporter cassette revealed that recombinase activity is first observed in the earliest limb bud at 9.5 dpc. By early to mid bud stages at 10.5 dpc recombination is essentially complete in all mesenchymal cells in the limb. Expression of the Cre recombinase was never detected in the limb bud ectoderm. The use of <jats:italic>Prx1</jats:italic>–<jats:italic>Cre</jats:italic> mice should facilitate analysis of gene function in the developing limb. genesis 33:77–80, 2002. © 2002 Wiley‐Liss, Inc.</jats:p>
収録刊行物
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- genesis
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genesis 33 (2), 77-80, 2002-05-08
Wiley
