Tyrosine Kinase Signaling in Kidney Glomerular Podocytes

Seisuke Hattori, Shoichiro Kanda, Yutaka Harita

doi:10.1155/2011/317852

Tyrosine Kinase Signaling in Kidney Glomerular Podocytes

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Seisuke Hattori

Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
Shoichiro Kanda

Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Yutaka Harita

Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

書誌事項

公開日: 2011-05-30

権利情報

http://creativecommons.org/licenses/by/3.0/

DOI

10.1155/2011/317852

公開者: Wiley

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説明

<jats:p>During the last decade, several key molecules have been identified as essential components for the filtration barrier function of kidney glomerular podocytes. Mutations in genes encoding these molecules severely impair the podocyte architecture in the affected patients, leading to the development of proteinuria. Extensive investigations have been performed on the function of these molecules, which highlights the importance of tyrosine kinase signaling in the podocytes. An Src family tyrosine kinase, Fyn, plays a major role in this signaling pathway. Here, we review the current understanding of this important signal transduction system and its role in the development and the maintenance of podocytes.</jats:p>