Weak Palindromic Consensus Sequences Are a Common Feature Found at the Integration Target Sites of Many Retroviruses
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- Xiaolin Wu
- Laboratory of Molecular Technology
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- Yuan Li
- AIDS Vaccine Program, Scientific Application International Corporation, National Cancer Institute at Frederick, Frederick
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- Bruce Crise
- AIDS Vaccine Program, Scientific Application International Corporation, National Cancer Institute at Frederick, Frederick
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- Shawn M. Burgess
- Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland
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- David J. Munroe
- Laboratory of Molecular Technology
説明
<jats:title>ABSTRACT</jats:title> <jats:p>Integration into the host genome is one of the hallmarks of the retroviral life cycle and is catalyzed by virus-encoded integrases. While integrase has strict sequence requirements for the viral DNA ends, target site sequences have been shown to be very diverse. We carefully examined a large number of integration target site sequences from several retroviruses, including human immunodeficiency virus type 1, simian immunodeficiency virus, murine leukemia virus, and avian sarcoma-leukosis virus, and found that a statistical palindromic consensus, centered on the virus-specific duplicated target site sequence, was a common feature at integration target sites for these retroviruses.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 79 (8), 5211-5214, 2005-04-15
American Society for Microbiology