Synthesis of a Sialic Acid Containing Complex‐Type <i>N</i>‐Glycan on a Solid Support
書誌事項
- 公開日
- 2009-03-30
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/asia.200800411
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p><jats:bold>On solid ground</jats:bold>: A new solid‐phase synthesis of <jats:italic>N</jats:italic>‐linked glycans featuring 1) highly stereoselective β‐mannosylation and microfluidic α‐sialylation and 2) efficient glycosylation of the <jats:italic>N</jats:italic>‐phenyltrifluoroacetimidate units on JandaJel resin is reported. Reagent concentration effects by a fluorous solvent are effectively applied, and the use of these methods results in the first synthesis of a sialic acid containing complex‐type <jats:italic>N</jats:italic>‐glycan on a solid support.<jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/gif" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/mcontent.gif"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p><jats:p>A new solid‐phase synthesis of <jats:italic>N</jats:italic>‐linked glycans featuring 1) highly stereoselective β‐mannosylation and microfluidic α‐sialylation and 2) efficient glycosylation of the <jats:italic>N</jats:italic>‐phenyltrifluoroacetimidate units on JandaJel resin is reported. Reagent concentration effects by a fluorous solvent are effectively applied, and the use of these methods results in the first synthesis of a sialic acid containing complex‐type <jats:italic>N</jats:italic>‐glycan on a solid support.</jats:p>
収録刊行物
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- Chemistry – An Asian Journal
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Chemistry – An Asian Journal 4 (4), 574-580, 2009-03-30
Wiley
