Nucleophilic Trifluoromethylthiolation of Alkyl Chlorides, Bromides and Tosylates

Chunfa Xu, Qingyun Chen, Qilong Shen

doi:10.1002/cjoc.201500905

Nucleophilic Trifluoromethylthiolation of Alkyl Chlorides, Bromides and Tosylates

DOI Web Site Web Site 被引用文献1件

書誌事項

公開日: 2016-03-08

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/cjoc.201500905

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>A direct nucleophilic trifluoromethylthiolation of alkyl chlorides, bromides and tosylates with AgSCF<jats:sub>3</jats:sub> was described. It was found that the presence of <jats:italic>n</jats:italic>Bu<jats:sub>4</jats:sub>NI or a combination of <jats:italic>n</jats:italic>Bu<jats:sub>4</jats:sub>NI/<jats:italic>n</jats:italic>Bu<jats:sub>4</jats:sub>NBr significantly enhanced the reaction rates. The reaction conditions were mild, thus allowing the tolerance of a variety of functional groups.</jats:p>