Bioimaging TOF‐SIMS: localization of cholesterol in rat kidney sections

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<jats:p>Rat kidneys were sectioned by cryoultramicrotomy and dried at room temperature. The samples were covered with a thin silver layer and analyzed in an imaging TOF‐SIMS instrument equipped with a Ga<jats:sup>+</jats:sup>‐source. The cholesterol signal showed a high concentration in the nuclear areas of the epithelial cells and a lower concentration over areas representing the basal lamina of renal tubules. A more diffuse distribution of cholesterol was also found over areas representing the cytoplasm or plasma membrane of the epithelial cells.</jats:p>

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  • FEBS Letters

    FEBS Letters 566 (1-3), 291-293, 2004-05-10

    Wiley

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