Differentiation of the Electrophysiological Effects on the Atrial Myocardium Between the Pure Na Channel Blocker, Pilsicainide, and Flecainide

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書誌事項

公開日
2004-07
権利情報
  • https://www.springernature.com/gp/researchers/text-and-data-mining
  • https://www.springernature.com/gp/researchers/text-and-data-mining
DOI
  • 10.1023/b:card.0000041249.35724.da
公開者
Springer Science and Business Media LLC

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説明

The purpose of this study was to identify the difference between the pure Na channel blocker, pilsicainide and Ic-antiarrhythmic drug, flecainide, on the atrial electrophysiological characteristics.The subjects consisted of 24 patients (48 +/- 12 years-old: P-group) in whom pilsicainide was administrated intravenously (1 mg/kg/10 min) and 31 patients (47 +/- 15 years-old: F-group) in whom flecainide was administrated intravenously (2 mg/kg/10 min). The atrial effective refractory period (ERP-A), intra-atrial conduction time (CT), max intra-atrial conduction delay (Max CD), repetitive atrial firing zone (RAFZ), fragmented atrial activity zone (FAZ) and intra-atrial conduction delay zone (CDZ) were measured before and after the drugs.Pilsicainide and flecainide significantly prolonged the ERP-A (211 +/- 27 msec to 246 +/- 39 msec; p0.001, 217 +/- 25 msec to 244 +/- 33 msec; p0.001, respectively) and CT (121 +/- 33 msec to 149 +/- 43 msec; p0.001, 122 +/- 22 msec to 153 +/- 27 msec; p0.001, respectively) to the same degree. However, the Max CD was shortened by pilsicainide, but not by flecainide. The RAFZ, FAZ and CDZ decreased in the P-group (21 +/- 25 msec to 4 +/- 10 msec; p0.01, 24 +/- 24 msec to 14 +/- 18 msec; p0.05, 56 +/- 29 msec to 43 +/- 32 msec, p0.05, respectively), but not in the F-group.The effects of atrial conduction delays may differ between pilsicainide and flecainide. Further examination will be needed to explain this mechanism.

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