The High-Resolution Crystal Structure of a Parallel-Stranded Guanine Tetraplex
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- Gerard Laughlan
- Medical Research Council Virology Unit, University of Glasgow, Glasgow G11 5JR, UK.
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- Alastair I. H. Murchie
- Cancer Research Campaign, Nucleic Acid Structure Research Group, Department of Biochemistry, The University, Dundee DD1 4HN, UK.
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- David G. Norman
- Cancer Research Campaign, Nucleic Acid Structure Research Group, Department of Biochemistry, The University, Dundee DD1 4HN, UK.
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- Madeleine H. Moore
- Department of Chemistry, York University, Heslington, York YO1 5DD, UK.
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- Peter C. E. Moody
- Department of Chemistry, York University, Heslington, York YO1 5DD, UK.
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- David M. J. Lilley
- Cancer Research Campaign, Nucleic Acid Structure Research Group, Department of Biochemistry, The University, Dundee DD1 4HN, UK.
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- Ben Luisi
- Medical Research Council Virology Unit, University of Glasgow, Glasgow G11 5JR, UK.
書誌事項
- 公開日
- 1994-07-22
- DOI
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- 10.1126/science.8036494
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:p> Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG <jats:sub>4</jats:sub> T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts. </jats:p>
収録刊行物
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- Science
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Science 265 (5171), 520-524, 1994-07-22
American Association for the Advancement of Science (AAAS)
