Selective and Scalable Synthesis of Trifluoromethanesulfenamides and Fluorinated Unsymmetrical Disulfides using a Shelf‐Stable Electrophilic SCF<sub>3</sub> Reagent

Roman Pluta, Magnus Rueping

doi:10.1002/chem.201405654

Selective and Scalable Synthesis of Trifluoromethanesulfenamides and Fluorinated Unsymmetrical Disulfides using a Shelf‐Stable Electrophilic SCF<sub>3</sub> Reagent

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書誌事項

公開日: 2014-11-07

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http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/chem.201405654

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>The chemoselective trifluoromethylthiolation of nitrogen nucleophiles and thiols using <jats:italic>N</jats:italic>‐(trifluoromethylthio)phthalimide under mild, metal‐free conditions is described. A series of trifluoromethanesulfenamides and unsymmetrical disulfides is prepared from the corresponding aliphatic and aromatic amines and thiols in good yields. The reactions are operationally simple and tolerate a wide variety of functional groups. Trifluoromethanesulfenamides and disulfides belong to interesting classes of organic molecules which possess remarkable properties for medicinal and agrochemical applications.</jats:p>