Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres

Myriam Drouin, Jean-François Paquin

doi:10.3762/bjoc.13.262

Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres

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書誌事項

公開日: 2017-12-12

権利情報

http://creativecommons.org/licenses/by/4.0
http://creativecommons.org/licenses/by/4.0
http://creativecommons.org/licenses/by/4.0

DOI

10.3762/bjoc.13.262

公開者: Beilstein Institut

説明

<jats:p>Monofluoroalkenes are fluorinated motifs that can be used to replace amide bonds. In order to be incorporated into peptides, it is normally necessary to first synthesize a dipeptide where the amide bond has been replaced with a monofluoroalkene. In that context, this review will present the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres described since 2007. Some applications of those compounds will also be presented.</jats:p>