The γ-Glutamyl Cycle: A Possible Transport System for Amino Acids

DOI Web Site 被引用文献11件
  • Marian Orlowski
    DEPARTMENT OF BIOCHEMISTRY, CORNELL UNIVERSITY MEDICAL COLLEGE, NEW YORK, N.Y. 10021
  • Alton Meister
    DEPARTMENT OF BIOCHEMISTRY, CORNELL UNIVERSITY MEDICAL COLLEGE, NEW YORK, N.Y. 10021

書誌事項

公開日
1970-11
DOI
  • 10.1073/pnas.67.3.1248
公開者
Proceedings of the National Academy of Sciences

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説明

<jats:p>Evidence is presented that rat kidney contains enzymes that catalyze the synthesis and utilization of glutathione; these reactions, which involve the uptake and release of amino acids from γ-glutamyl linkage, constitute a cyclical process which is termed „the γ-glutamyl cycle.” The γ-glutamyl cycle has properties that fulfill the requirements of an amino acid transport system. Thus, γ-glutamyl transpeptidase may function in translocation and γ-glutamylcysteine synthetase and glutathione synthetase may catalyze energy-requiring „recovery” steps in transport. These and other considerations suggest that glutathione serves a carrier function in amino acid transport.</jats:p>

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