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- Andreas A. Linninger
- Laboratory for Product and Process Design, Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607;
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- Kevin Tangen
- Laboratory for Product and Process Design, Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607;
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- Chih-Yang Hsu
- Laboratory for Product and Process Design, Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607;
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- David Frim
- Department of Neurosurgery, University of Chicago, Chicago, Illinois 60637
説明
<jats:p> Cerebrospinal fluid (CSF) is not stagnant but displays fascinating oscillatory flow patterns inside the ventricular system and reversing fluid exchange between the cranial vault and spinal compartment. This review provides an overview of the current knowledge of pulsatile CSF motion. Observations contradicting classical views about its bulk production and clearance are highlighted. A clinical account of diseases of abnormal CSF flow dynamics, including hydrocephalus, syringomyelia, Chiari malformation type 1, and pseudotumor cerebri, is also given. We survey medical imaging modalities used to observe intracranial dynamics in vivo. Additionally, we assess the state of the art in predictive models of CSF dynamics. The discussion addresses open questions regarding CSF dynamics as they relate to the understanding and management of diseases. </jats:p>
収録刊行物
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- Annual Review of Fluid Mechanics
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Annual Review of Fluid Mechanics 48 (1), 219-257, 2016-01-03
Annual Reviews