Molecular Determinants of Topoisomerase I Poisoning by Lamellarins:  Comparison with Camptothecin and Structure−Activity Relationships

  • Esther Marco
    Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, F-59045 Lille, France, and Faculty of Engineering and Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan
  • William Laine
    Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, F-59045 Lille, France, and Faculty of Engineering and Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan
  • Christelle Tardy
    Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, F-59045 Lille, France, and Faculty of Engineering and Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan
  • Amélie Lansiaux
    Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, F-59045 Lille, France, and Faculty of Engineering and Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan
  • Masatomo Iwao
    Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, F-59045 Lille, France, and Faculty of Engineering and Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan
  • Fumito Ishibashi
    Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, F-59045 Lille, France, and Faculty of Engineering and Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan
  • Christian Bailly
    Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, F-59045 Lille, France, and Faculty of Engineering and Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan
  • Federico Gago
    Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, F-59045 Lille, France, and Faculty of Engineering and Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan

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