The Anticollagenolytic Potential of Lymecycline in the Long‐Term Treatment of Reactive Arthritis

DOI Web Site Web Site 被引用文献2件

この論文をさがす

説明

<jats:title>Abstract</jats:title><jats:p><jats:italic>Objective.</jats:italic> We sought to determine the antiinflammatory properties of lymecycline in the long‐term treatment of reactive arthritis (ReA).</jats:p><jats:p><jats:italic>Methods.</jats:italic> Quantitative assay of collagenase activity by densitometry after sodium dodecyl sulfatepolyacrylamide gel electrophoresis.</jats:p><jats:p><jats:italic>Results.</jats:italic> Therapeutic levels of lymecycline do not directly inhibit the activity of human neutrophil interstitial collagenase, but can prevent the oxidative activation of latent human neutrophil collagenase.</jats:p><jats:p><jats:italic>Conclusion.</jats:italic> This non‐antimicrobial, anticollagenolytic property of lymecycline may contribute to its therapeutic efficacy in the treatment of patients with ReA.</jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ