Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response to <i>Klebsiella pneumoniae</i> Infection
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- Kyle I Happel
- Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Mingquan Zheng
- Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Erana Young
- Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Lee J Quinton
- Alcohol Research Center, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Euan Lockhart
- Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Alistair J Ramsay
- Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Judd E Shellito
- Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Jill R Schurr
- Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Gregory J Bagby
- Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Steve Nelson
- Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112
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- Jay K Kolls
- Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112
書誌事項
- 公開日
- 2003-05-01
- 権利情報
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- https://academic.oup.com/pages/standard-publication-reuse-rights
- DOI
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- 10.4049/jimmunol.170.9.4432
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Local production of IL-17 is a significant factor in effective host defense against Gram-negative bacteria. However, the proximal events mediating IL-17 elaboration by T cells remain unclear. In this study, we show in vivo that intact Toll-like receptor 4 signaling in the lung is required for induction of both the p19 transcript of IL-23 and IL-17 protein elaboration in response to Klebsiella pneumoniae. Although IL-17 is widely considered a CD4+ T cell product, we also demonstrate significant in vitro IL-17 production by CD8+ T cells after culture in medium from dendritic cells exposed to these bacteria. The dominant portion of this IL-17-inducing activity for both CD4+ and CD8+ T cells is IL-23. These data demonstrate the critical signaling pathway for IL-17 induction in the host response to Gram-negative pulmonary infection and suggest a direct role for IL-23 in CD8+ T cell IL-17 production.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 170 (9), 4432-4436, 2003-05-01
Oxford University Press (OUP)
