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- Meisheng Yi
- Department of Biological Sciences, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260.
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- Ni Hong
- Department of Biological Sciences, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260.
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- Yunhan Hong
- Department of Biological Sciences, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260.
書誌事項
- 公開日
- 2009-10-16
- DOI
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- 10.1126/science.1175151
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Haploid Medaka Stem Cells</jats:title> <jats:p> Although diploid embryonic stem cells have been generated by various means, there would also be value in deriving haploid stem cells. In these cells, recessive mutations in essential genes would show phenotypes that would not be apparent in heterozygous animals. <jats:bold> Yi <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="430" related-article-type="in-this-issue" vol="326" xlink:href="10.1126/science.1175151">430</jats:related-article> ) used the medaka fish model system to generate haploid stem cells that show stable growth and pluripotency. In addition, a fertile female medaka fish was produced by haploid embryonic stem cell nuclear transfer into a normal egg. This system has potential for analyzing recessive genes, for example, in disease phenotypes or in various cell lineages in culture. </jats:p>
収録刊行物
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- Science
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Science 326 (5951), 430-433, 2009-10-16
American Association for the Advancement of Science (AAAS)
