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- Edna Regina Silva Pereira Caetano
- From the Renal Division, Department of Clinical Medicine (E.R.S.P.C., R.Z., J.N.P.), and the Department of Pathology, Faculty of Medicine (L.B.S.), University of São Paulo, São Paulo, Brazil
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- Roberto Zatz
- From the Renal Division, Department of Clinical Medicine (E.R.S.P.C., R.Z., J.N.P.), and the Department of Pathology, Faculty of Medicine (L.B.S.), University of São Paulo, São Paulo, Brazil
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- Luís Balthazar Saldanha
- From the Renal Division, Department of Clinical Medicine (E.R.S.P.C., R.Z., J.N.P.), and the Department of Pathology, Faculty of Medicine (L.B.S.), University of São Paulo, São Paulo, Brazil
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- José Nery Praxedes
- From the Renal Division, Department of Clinical Medicine (E.R.S.P.C., R.Z., J.N.P.), and the Department of Pathology, Faculty of Medicine (L.B.S.), University of São Paulo, São Paulo, Brazil
書誌事項
- 公開日
- 2001-08
- DOI
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- 10.1161/01.hyp.38.2.171
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
この論文をさがす
説明
<jats:p>It is currently unclear whether hypertensive nephrosclerosis (HN), usually diagnosed solely on clinical grounds, is a relevant cause of end-stage renal disease. We biopsied 81 hypertensive outpatients (blood pressure ≥160/95 mm Hg) with moderate renal insufficiency, who were referred to our service from 1988 to 1998. Patients with known causes of hypertension, systemic disorders, rheumatic disease, or nephrotic syndrome were excluded. In 65% of patients, HN was the sole histological abnormality associated with renal dysfunction. Benign nephrosclerosis (BN), defined as isolated arteriolar hyalinosis and/or intimal fibrosis, was found in 18 HN patients (22%), whereas malignant nephrosclerosis (MN), denoted mainly by myointimal cell proliferation, appeared in 35 HN patients (43%). Previously undiagnosed primary nephritis (PN) was found in 13 patients (16%), whereas focal and segmental glomerulosclerosis, which might be either primary or secondary to hypertension, appeared in 15 patients (19%). These findings suggest that HN, in both its BN and MN forms, can be a definite cause of chronic renal insufficiency and that a substantial fraction of patients with renal insufficiency and clinical diagnosis of HN may actually have PN.</jats:p>
収録刊行物
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- Hypertension
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Hypertension 38 (2), 171-176, 2001-08
Ovid Technologies (Wolters Kluwer Health)
