Invariant Vα19i T cells regulate autoimmune inflammation

DOI PDF Web Site PubMed 被引用文献27件

書誌事項

公開日
2006-07-30
権利情報
  • http://www.springer.com/tdm
DOI
  • 10.1038/ni1370
公開者
Springer Science and Business Media LLC

この論文をさがす

説明

T cells expressing an invariant V(alpha)19-J(alpha)33 T cell receptor alpha-chain (V(alpha)19i TCR) are restricted by the nonpolymorphic major histocompatibility complex class Ib molecule MR1. Whether V(alpha)19i T cells are involved in autoimmunity is not understood. Here we demonstrate that T cells expressing the V(alpha)19i TCR transgene inhibited the induction and progression of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Similarly, EAE was exacerbated in MR1-deficient mice, which lack V(alpha)19i T cells. EAE suppression was accompanied by reduced production of inflammatory mediators and increased secretion of interleukin 10. Interleukin 10 production occurred at least in part through interactions between B cells and V(alpha)19i T cells mediated by the ICOS costimulatory molecule. These results suggest an immunoregulatory function for V(alpha)19i T cells.

収録刊行物

  • Nature Immunology

    Nature Immunology 7 (9), 987-994, 2006-07-30

    Springer Science and Business Media LLC

被引用文献 (27)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ