Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine
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- Shai Bel
- Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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- Mihir Pendse
- Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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- Yuhao Wang
- Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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- Yun Li
- Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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- Kelly A. Ruhn
- Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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- Brian Hassell
- Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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- Tess Leal
- Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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- Sebastian E. Winter
- Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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- Ramnik J. Xavier
- Broad Institute, Cambridge, MA 02142, USA.
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- Lora V. Hooper
- Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
書誌事項
- 公開日
- 2017-09-08
- DOI
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- 10.1126/science.aal4677
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Foiling bad bugs' sneaky tricks</jats:title> <jats:p> Intestinal pathogens can invade host cells and disrupt critical cellular functions, including secretion. Secretion is necessary for the delivery of antimicrobial proteins that kill pathogenic bacteria. Bel <jats:italic>et al.</jats:italic> show that when intestinal epithelial cells sense an invading bacterial pathogen, they “reroute” the antimicrobial protein lysozyme through an alternative autophagy-based secretion pathway (see the Perspective by Kaser and Blumberg). This ensures lysozyme delivery to the gut lumen, which protects against further bacterial invasion. Secretory autophagy was triggered by endoplasmic reticulum stress and required signals from type 3 innate lymphoid cells. Thus, the innate immune response to gut pathogens co-opts autophagy in intestinal immune defense. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1047" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aal4677">1047</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="976" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao4158">976</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 357 (6355), 1047-1052, 2017-09-08
American Association for the Advancement of Science (AAAS)
