Eph/ephrin molecules—a hub for signaling and endocytosis

DOI Web Site 被引用文献13件

書誌事項

公開日
2010-11-15
DOI
  • 10.1101/gad.1973910
公開者
Cold Spring Harbor Laboratory

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説明

<jats:p>The development, homeostasis, and regeneration of complex organ systems require extensive cell–cell communication to ensure that different cells proliferate, migrate, differentiate, assemble, and function in a coordinated and timely fashion. Eph receptor tyrosine kinases and their ephrin ligands are critical regulators of cell contact-dependent signaling and patterning. Eph/ephrin binding can lead to very diverse biological readouts such as adhesion versus repulsion, or increased versus decreased motility. Accordingly, depending on cell type and context, a limited and conserved set of receptor–ligand interactions is translated into a large variety of downstream signaling processes. Recent evidence indicates that the endocytosis of Eph/ephrin molecules, together with the internalization of various associated tissue-specific effectors, might be one of the key principles responsible for such highly diverse and adaptable biological roles. Here, we summarize recent insights into Eph/ephrin signaling and endocytosis in three biological systems; i.e., the brain, intestine, and vasculature.</jats:p>

収録刊行物

  • Genes & Development

    Genes & Development 24 (22), 2480-2492, 2010-11-15

    Cold Spring Harbor Laboratory

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