Golgi-derived PI <b>(</b> 4 <b>)</b> P-containing vesicles drive late steps of mitochondrial division
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- Luis-Carlos Tábara
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
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- Shun Nagashima
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
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- Lisa Tilokani
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
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- Joe H. Pogson
- Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3B 2B4, Canada.
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- Heidi M. McBride
- Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3B 2B4, Canada.
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- Rodolfo Zunino
- Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3B 2B4, Canada.
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- Vincent Paupe
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
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- Hanish Anand
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
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- Julien Prudent
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
書誌事項
- 公開日
- 2020-03-20
- DOI
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- 10.1126/science.aax6089
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:title>PI(4)P regulates mitochondrial fission</jats:title> <jats:p> Mitochondria are dynamic intracellular organelles, the shape and number of which are regulated by various cell-signaling pathways. Mitochondrial division is driven by the recruitment of a constricting guanosine triphosphatase protein at sites of contact with the endoplasmic reticulum, but other factors, including lysosomes, are also involved. Nagashima <jats:italic>et al.</jats:italic> now document an essential role for Golgi-derived vesicles bearing a specific lipid—phosphatidylinositol 4-phosphate, or PI(4)P—in the final steps of mitochondrial division. Disruption of PI(4)P production results in mitochondrial morphological defects indicative of an inability to complete fission. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6484" page="1366" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aax6089">1366</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 367 (6484), 1366-1371, 2020-03-20
American Association for the Advancement of Science (AAAS)
