PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
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- Taiji Tsunemi
- Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
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- Travis D. Ashe
- Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
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- Bradley E. Morrison
- Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
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- Kathryn R. Soriano
- Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
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- Jonathan Au
- Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
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- Ruben A. Vázquez Roque
- Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
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- Eduardo R. Lazarowski
- Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
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- Vincent A. Damian
- Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
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- Eliezer Masliah
- Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
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- Albert R. La Spada
- Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
説明
<jats:p>PGC-1α rescues Huntington’s disease neurodegeneration by reducing reactive oxygen species and inducing a master regulator of autophagy.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 4 (142), 142ra197-, 2012-07-11
American Association for the Advancement of Science (AAAS)
