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- Chie Watanabe
- Department of Immunology
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- Geraldine L. Shu
- Department of Microbiology, University of Washington , Seattle, WA 98195
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- Timothy S. Zheng
- Department of Immunobiology, Yale University of School of Medicine , New Haven, CT 06520
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- Richard A. Flavell
- Department of Immunobiology, Yale University of School of Medicine , New Haven, CT 06520
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- Edward A. Clark
- Department of Immunology
書誌事項
- 公開日
- 2008-11
- 権利情報
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- https://academic.oup.com/pages/standard-publication-reuse-rights
- DOI
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- 10.4049/jimmunol.181.10.6810
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Caspase (Casp) family proteases regulate not only lymphocyte apoptosis but also lymphocyte activation and development. In this study, we show that Casp6 regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry. B cells from Casp6 knockout (Casp6 KO) mice examined ex vivo have more cells in G1 than wild-type B cells, and mitogen-induced G1 entry of Casp6 KO B cells is much faster than that of wild-type B cells. Even so, S phase entry and proliferation are not increased in Casp6 KO B cells. Rather than proliferating, activated Casp6 KO B cells preferentially differentiate into syndecan-1+ plasma cells and produce Abs. In Casp6 KO mice compared with WT mice, serum levels of IgG1, IgG2a, and IgG2b are increased and Ag-specific Ab responses are also enhanced along with increased percentages of syndecan-1+ plasma cells. Casp6 may regulate both B cell activation and differentiation by modifying requirements for G0 B cells to enter G1.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 181 (10), 6810-6819, 2008-11
Oxford University Press (OUP)
