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- Raquel Bartolomé-Casado
- Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
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- Ole J.B. Landsverk
- Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
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- Sudhir Kumar Chauhan
- Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
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- Lisa Richter
- Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
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- Danh Phung
- Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
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- Victor Greiff
- Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
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- Louise F. Risnes
- Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway 5
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- Ying Yao
- Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
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- Ralf S. Neumann
- Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
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- Sheraz Yaqub
- Department of Gastrointestinal Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway 7
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- Ole Øyen
- Department of Transplantation Medicine, Section for Transplant Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway 8
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- Rune Horneland
- Department of Transplantation Medicine, Section for Transplant Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway 8
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- Einar Martin Aandahl
- Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway 2
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- Vemund Paulsen
- Department of Gastroenterology, Oslo University Hospital, Rikshospitalet, Oslo, Norway 9
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- Ludvig M. Sollid
- Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
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- Shuo-Wang Qiao
- Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4
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- Espen S. Baekkevold
- Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
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- Frode L. Jahnsen
- Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway 1
説明
<jats:p>Resident memory CD8 T (Trm) cells have been shown to provide effective protective responses in the small intestine (SI) in mice. A better understanding of the generation and persistence of SI CD8 Trm cells in humans may have implications for intestinal immune-mediated diseases and vaccine development. Analyzing normal and transplanted human SI, we demonstrated that the majority of SI CD8 T cells were bona fide CD8 Trm cells that survived for >1 yr in the graft. Intraepithelial and lamina propria CD8 Trm cells showed a high clonal overlap and a repertoire dominated by expanded clones, conserved both spatially in the intestine and over time. Functionally, lamina propria CD8 Trm cells were potent cytokine producers, exhibiting a polyfunctional (IFN-γ+ IL-2+ TNF-α+) profile, and efficiently expressed cytotoxic mediators after stimulation. These results suggest that SI CD8 Trm cells could be relevant targets for future oral vaccines and therapeutic strategies for gut disorders.</jats:p>
収録刊行物
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- Journal of Experimental Medicine
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Journal of Experimental Medicine 216 (10), 2412-2426, 2019-07-23
Rockefeller University Press
