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- Gervaise Loirand
- From the From INSERM U-533-Institut du Thorax, Faculté des Sciences, Nantes, France.
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- Patrice Guérin
- From the From INSERM U-533-Institut du Thorax, Faculté des Sciences, Nantes, France.
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- Pierre Pacaud
- From the From INSERM U-533-Institut du Thorax, Faculté des Sciences, Nantes, France.
抄録
<jats:p>Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have been found to regulate a wide range of fundamental cell functions such as contraction, motility, proliferation, and apoptosis. Abnormal activation of the RhoA/ROCK pathway has been observed in major cardiovascular disorders such as atherosclerosis, restenosis, hypertension, pulmonary hypertension, and cardiac hypertrophy. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling and its roles in cardiovascular physiology and pathophysiology.</jats:p>
収録刊行物
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- Circulation Research
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Circulation Research 98 (3), 322-334, 2006-02-17
Ovid Technologies (Wolters Kluwer Health)