Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off
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- Luk Van Parijs
- The authors are in the Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Abul K. Abbas
- The authors are in the Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Description
<jats:p>The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.</jats:p>
Journal
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- Science
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Science 280 (5361), 243-248, 1998-04-10
American Association for the Advancement of Science (AAAS)
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Details 詳細情報について
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- CRID
- 1363388845077656960
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- NII Article ID
- 30020367061
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- ISSN
- 10959203
- 00368075
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- Data Source
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- Crossref
- CiNii Articles