Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

DOI Web Site 被引用文献9件
  • Luk Van Parijs
    The authors are in the Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Abul K. Abbas
    The authors are in the Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

説明

<jats:p>The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.</jats:p>

収録刊行物

  • Science

    Science 280 (5361), 243-248, 1998-04-10

    American Association for the Advancement of Science (AAAS)

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