Preparation of a new chiral building block containing a benzylic quaternary stereogenic center and a formal total synthesis of (−)-physostigmine

Kaori Asakawa, Naoyoshi Noguchi, Shingo Takashima, Masahisa Nakada

doi:10.1016/j.tetasy.2008.09.021

Preparation of a new chiral building block containing a benzylic quaternary stereogenic center and a formal total synthesis of (−)-physostigmine

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書誌事項

公開日: 2008-10

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DOI

10.1016/j.tetasy.2008.09.021

公開者: Elsevier BV

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説明

Abstract This paper describes the preparation of a new chiral building block containing a benzylic quaternary stereogenic center via the highly enantioselective PLE-mediated hydrolysis of dimethyl 2-(2-chloro-5-methoxyphenyl)-2-methylmalonate, as well as the absolute configuration of the new chiral building block, which has been elucidated through the formal total synthesis of (−)-physostigmine.