Direct Trifluoromethylthiolation of Unactivated C(sp<sup>3</sup>)H Using Silver(I) Trifluoromethanethiolate and Potassium Persulfate

Hao Wu, Zhiwei Xiao, Junhui Wu, Yong Guo, Ji‐Chang Xiao, Chao Liu, Qing‐Yun Chen

doi:10.1002/ange.201411953

Direct Trifluoromethylthiolation of Unactivated C(sp<sup>3</sup>)H Using Silver(I) Trifluoromethanethiolate and Potassium Persulfate

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書誌事項

公開日: 2015-02-23

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http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/ange.201411953

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>A practical and efficient method for the direct trifluoromethylthiolation of unactivated C(sp<jats:sup>3</jats:sup>)H bonds by AgSCF<jats:sub>3</jats:sub>/K<jats:sub>2</jats:sub>S<jats:sub>2</jats:sub>O<jats:sub>8</jats:sub> under mild conditions is described. The reaction has a good functional‐group tolerance and good selectivity. Initial mechanistic investigations indicate that the reaction may involve a radical process in which K<jats:sub>2</jats:sub>S<jats:sub>2</jats:sub>O<jats:sub>8</jats:sub> plays key roles in both the activation of the C(sp<jats:sup>3</jats:sup>)H bond and the oxidation of AgSCF<jats:sub>3</jats:sub>.</jats:p>