Role of Melanopsin in Circadian Responses to Light

DOI Web Site 被引用文献22件
  • Norman F. Ruby
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.
  • Thomas J. Brennan
    Deltagen, Inc., Redwood City, CA 94063, USA.
  • Xinmin Xie
    Deltagen, Inc., Redwood City, CA 94063, USA.
  • Vinh Cao
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.
  • Paul Franken
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.
  • H. Craig Heller
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.
  • Bruce F. O'Hara
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.

書誌事項

公開日
2002-12-13
DOI
  • 10.1126/science.1076701
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p> Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to a light/dark cycle, phase-shifted after a light pulse, and increased circadian period when light intensity increased. Induction of the immediate-early gene c- <jats:italic>fos</jats:italic> was observed after a nighttime light pulse in both wild-type and knockout mice. However, the magnitude of these behavioral responses in knockout mice was 40% lower than in wild-type mice. Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses. </jats:p>

収録刊行物

  • Science

    Science 298 (5601), 2211-2213, 2002-12-13

    American Association for the Advancement of Science (AAAS)

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