MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

DOI PDF PubMed 被引用文献114件 オープンアクセス
  • Rintaro Shimazu
    From the Department of Immunology, Saga Medical School, Saga, Japan
  • Sachiko Akashi
    From the Department of Immunology, Saga Medical School, Saga, Japan
  • Hirotaka Ogata
    From the Department of Immunology, Saga Medical School, Saga, Japan
  • Yoshinori Nagai
    From the Department of Immunology, Saga Medical School, Saga, Japan
  • Kenji Fukudome
    From the Department of Immunology, Saga Medical School, Saga, Japan
  • Kensuke Miyake
    From the Department of Immunology, Saga Medical School, Saga, Japan
  • Masao Kimoto
    From the Department of Immunology, Saga Medical School, Saga, Japan

書誌事項

公開日
1999-06-07
DOI
  • 10.1084/jem.189.11.1777
公開者
Rockefeller University Press

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説明

<jats:p>Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently been shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS). TLR4 may be a long-sought receptor for LPS. However, transfection of TLR4 does not confer LPS responsiveness on a recipient cell line, suggesting a requirement for an additional molecule. Here, we report that a novel molecule, MD-2, is requisite for LPS signaling of TLR4. MD-2 is physically associated with TLR4 on the cell surface and confers responsiveness to LPS. MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms.</jats:p>

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