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- Dejian Ren
- Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania
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- Jingsheng Xia
- Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania
説明
<jats:p>The molecular mechanisms underlying Ca<jats:sup>2+</jats:sup>entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca<jats:sup>2+</jats:sup>entry through CatSper channels instead of acting on Ca<jats:sub>V</jats:sub>and CNG channels as previously thought.</jats:p>
収録刊行物
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- Physiology
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Physiology 25 (3), 165-175, 2010-06
American Physiological Society
