Conservation and evolution of gene coexpression networks in human and chimpanzee brains
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- Michael C. Oldham
- *Interdepartmental Program for Neuroscience,
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- Steve Horvath
- Departments of §Biostatistics,
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- Daniel H. Geschwind
- Human Genetics, and
書誌事項
- 公開日
- 2006-11-21
- DOI
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- 10.1073/pnas.0605938103
- 公開者
- Proceedings of the National Academy of Sciences
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説明
<jats:p>Comparisons of gene expression between human and non-human primate brains have identified hundreds of differentially expressed genes, yet translating these lists into key functional distinctions between species has proved difficult. Here we provide a more integrated view of human brain evolution by examining the large-scale organization of gene coexpression networks in human and chimpanzee brains. We identify modules of coexpressed genes that correspond to discrete brain regions and quantify their conservation between the species. Module conservation in cerebral cortex is significantly weaker than module conservation in subcortical brain regions, revealing a striking gradient that parallels known evolutionary hierarchies. We introduce a method for identifying species-specific network connections and demonstrate how differential network connectivity can be used to identify key drivers of evolutionary change. By integrating our results with comparative genomic sequence data and estimates of protein sequence divergence rates, we confirm a number of network predictions and validate these findings. Our results provide insights into the molecular bases of primate brain organization and demonstrate the general utility of weighted gene coexpression network analysis.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 103 (47), 17973-17978, 2006-11-21
Proceedings of the National Academy of Sciences
