Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
書誌事項
- 公開日
- 2012
- DOI
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- 10.3748/wjg.v18.i19.2300
- 公開者
- Baishideng Publishing Group Inc.
この論文をさがす
説明
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma. NAFLD is regarded as a hepatic manifestation of metabolic syndrome and incidence has been increasing worldwide in line with the increased prevalence of obesity, type 2 diabetes, and hyperlipemia. Animal models of NAFLD/NASH give crucial information, not only in elucidating pathogenesis of NAFLD/NASH but also in examining therapeutic effects of various agents. An ideal model of NAFLD/NASH should correctly reflect both hepatic histopathology and pathophysiology of human NAFLD/NASH. Animal models of NAFLD/NASH are divided into genetic, dietary, and combination models. In this paper, we review commonly used animal models of NAFLD/NASH referring to their advantages and disadvantages.
収録刊行物
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- World Journal of Gastroenterology
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World Journal of Gastroenterology 18 (19), 2300-, 2012
Baishideng Publishing Group Inc.
