Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction

DOI Web Site 被引用文献19件
  • Luciano C. Amado
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Anastasios P. Saliaris
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Karl H. Schuleri
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Marcus St. John
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Jin-Sheng Xie
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Stephen Cattaneo
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Daniel J. Durand
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Torin Fitton
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Jin Qiang Kuang
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Garrick Stewart
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Stephanie Lehrke
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • William W. Baumgartner
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Bradley J. Martin
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Alan W. Heldman
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043
  • Joshua M. Hare
    Department of Medicine, Cardiology Division, and Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287; Institute for Cell Engineering, Broadway Research Building, Suite 651, 733 North Broadway,The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043

抄録

<jats:p>Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate promising results, many practical and mechanistic issues regarding this therapy remain highly controversial. Here, we report the results of a randomized study of bone-marrow-derived mesenchymal stem cells, administered to pigs, which offer several new insights regarding cellular cardiomyoplasty. First, cells were safely injected by using a percutaneous-injection catheter 3 d after myocardial infarction. Second, cellular transplantation resulted in long-term engraftment, profound reduction in scar formation, and near-normalization of cardiac function. Third, transplanted cells were preprepared from an allogeneic donor and were not rejected, a major practical advance for widespread application of this therapy. Together, these findings demonstrate that the direct injection of cellular grafts into damaged myocardium is safe and effective in the periinfarct period. The direct delivery of cells to necrotic myocardium offers a valuable alternative to intracoronary cell injections, and the use of allogeneic mesenchymal stem cells provides a valuable strategy for cardiac regenerative therapy that avoids the need for preparing autologous cells from the recipient.</jats:p>

収録刊行物

被引用文献 (19)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ