α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1
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- Mark R. Silvis
- Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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- Bridget T. Kreger
- Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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- Wen-Hui Lien
- Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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- Olga Klezovitch
- Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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- G. Marianna Rudakova
- Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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- Fernando D. Camargo
- Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
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- Dan M. Lantz
- Dermatopathology Northwest, 2330 130th Avenue NE, Bellevue, WA 98005, USA.
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- John T. Seykora
- Department of Dermatology, University of Pennsylvania Medical School, Philadelphia, PA 19101, USA.
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- Valeri Vasioukhin
- Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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説明
<jats:p>A cell-cell adhesion protein suppresses skin carcinoma development by attenuating the signaling of a transcriptional coactivator in the Hippo pathway.</jats:p>
収録刊行物
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- Science Signaling
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Science Signaling 4 (174), ra33-, 2011-05-24
American Association for the Advancement of Science (AAAS)
