Contribution of <i>vraSR</i> and <i>graSR</i> Point Mutations to Vancomycin Resistance in Vancomycin-Intermediate <i>Staphylococcus aureus</i>
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- Longzhu Cui
- Department of Bacteriology
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- Hui-min Neoh
- Department of Bacteriology
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- Mitsutaka Shoji
- Department of Infection Control Science, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan
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- Keiichi Hiramatsu
- Department of Bacteriology
書誌事項
- 公開日
- 2009-03
- 権利情報
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/aac.01173-08
- 公開者
- American Society for Microbiology
この論文をさがす
説明
<jats:title>ABSTRACT</jats:title> <jats:p> We describe here the genetic analysis of a vancomycin-susceptible <jats:italic>Staphylococcus aureus</jats:italic> (VSSA) strain, Mu50Ω, a strain related to vancomycin-intermediate <jats:italic>S. aureus</jats:italic> (VISA) strain Mu50. Using a combination of Mu50Ω whole-genome sequencing and genome engineering, we observed a stepwise evolution of vancomycin resistance from VSSA to VISA after the mutated <jats:italic>vraS</jats:italic> and <jats:italic>graR</jats:italic> genes of Mu50 were engineered into Mu50Ω. </jats:p>
収録刊行物
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 53 (3), 1231-1234, 2009-03
American Society for Microbiology
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キーワード
- Staphylococcus aureus
- Base Sequence
- Sequence Homology, Amino Acid
- Molecular Sequence Data
- Vancomycin Resistance
- Microbial Sensitivity Tests
- Sequence Analysis, DNA
- Anti-Bacterial Agents
- DNA-Binding Proteins
- Chromosome Walking
- Bacterial Proteins
- Vancomycin
- Humans
- Point Mutation
- Amino Acid Sequence
- Genetic Engineering
- Genome, Bacterial
詳細情報 詳細情報について
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- CRID
- 1363670319026168960
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- ISSN
- 10986596
- 00664804
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- PubMed
- 19124662
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- データソース種別
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- Crossref
- OpenAIRE