Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery

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  • Wei Zhu
    Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico Albuquerque NM 87131 USA
  • Jimin Guo
    Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico Albuquerque NM 87131 USA
  • Yi Ju
    ARC Centre of Excellence in Convergent Bio–Nano Science and Technology and The Department of Chemical Engineering The University of Melbourne Parkville Victoria 3010 Australia
  • Rita E. Serda
    Department of Internal Medicine Molecular Medicine The University of New Mexico Albuquerque NM 87131 USA
  • Jonas G. Croissant
    Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico Albuquerque NM 87131 USA
  • Jin Shang
    School of Energy and Environment City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong SAR P. R. China
  • Eric Coker
    Sandia National Laboratories Applied Optical/Plasma Sciences P.O. Box 5800, MS 1411 Albuquerque NM 87185‐1411 USA
  • Jacob Ongudi Agola
    Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico Albuquerque NM 87131 USA
  • Qi‐Zhi Zhong
    ARC Centre of Excellence in Convergent Bio–Nano Science and Technology and The Department of Chemical Engineering The University of Melbourne Parkville Victoria 3010 Australia
  • Yuan Ping
    College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 P. R. China
  • Frank Caruso
    ARC Centre of Excellence in Convergent Bio–Nano Science and Technology and The Department of Chemical Engineering The University of Melbourne Parkville Victoria 3010 Australia
  • C. Jeffrey Brinker
    Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico Albuquerque NM 87131 USA

書誌事項

公開日
2019-01-31
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#am
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/adma.201806774
公開者
Wiley

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<jats:title>Abstract</jats:title><jats:p>Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal–organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well‐defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one‐pot process for versatile bioapplications. The MOP superassemblies are surface‐engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half‐life of 5.6 h and to undergo renal clearance—characteristics needed for nanomedicines.</jats:p>

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