Effects of Sairei-To on the Relapse of Steroid-Dependent Nephrotic Syndrome

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  • Kenijiro Kimura
    The Second Department of Internal Medicine, Faculty of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
  • Shinichiro Nanba
    The Second Department of Internal Medicine, Faculty of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
  • Akihiro Tojo
    The Second Department of Internal Medicine, Faculty of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
  • Hiroaki Matsuoka
    The Second Department of Internal Medicine, Faculty of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
  • Tsuneaki Sugimoto
    The Second Department of Internal Medicine, Faculty of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

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<jats:p> Sairei-To (Chai-Ling-Tang) was administered to four patients with steroid-dependent relapsing nephrotic syndrome. It was associated with prednisolone and immunosuppressive agents. Histological diagnosis was minimal change in three patients and mild focal glomerulonephritis in one patient. After the start of Sairei-To administration the relapse was markedly suppressed in three patients but not at all in the other. Although we could consider Sairei-To effective for steroid-dependent nephrotic syndrome in the present study, a larger study is necessary to confirm its efficacy. </jats:p>

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