Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated leukocytes

DOI Web Site Web Site PubMed 被引用文献19件

書誌事項

公開日
2000-02
権利情報
  • https://www.elsevier.com/tdm/userlicense/1.0/
DOI
  • 10.1016/s0304-3835(99)00351-1
公開者
Elsevier BV

この論文をさがす

説明

Excessive and prolonged generation of superoxide (O2-) and nitric oxide (NO) from inflammatory leukocytes is associated with several lifestyle-related diseases, including cancer. In the present study, we screened 19 natural carotenoids for their modifying effects on O2- and NO generation from differentiated human promyelocytic HL-60 cells and mouse macrophage RAW 264.7 cells, respectively. Of the carotenoids tested, halocynthiaxanthin, isolated from oysters, showed the highest suppressive effect on the generation of both free radicals. The inhibitory potencies of certain carotenoids on radical generation markedly exceeded that of beta-carotene. In addition, some important structural moieties regulating radical generation suppression are discussed.

収録刊行物

  • Cancer Letters

    Cancer Letters 149 (1-2), 115-123, 2000-02

    Elsevier BV

被引用文献 (19)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ