Imaging Experimental Cerebral Malaria<i>In Vivo</i>: Significant Role of Ischemic Brain Edema
書誌事項
- 公開日
- 2005-08-10
- 権利情報
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- https://creativecommons.org/licenses/by-nc-sa/4.0/
- DOI
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- 10.1523/jneurosci.1002-05.2005
- 公開者
- Society for Neuroscience
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説明
<jats:p>The first<jats:italic>in vivo</jats:italic>magnetic resonance study of experimental cerebral malaria is presented. Cerebral involvement is a lethal complication of malaria. To explore the brain of susceptible mice infected with<jats:italic>Plasmodium berghei</jats:italic>ANKA, multimodal magnetic resonance techniques were applied (imaging, diffusion, perfusion, angiography, spectroscopy). They reveal vascular damage including blood-brain barrier disruption and hemorrhages attributable to inflammatory processes. We provide the first<jats:italic>in vivo</jats:italic>demonstration for blood-brain barrier breakdown in cerebral malaria. Major edema formation as well as reduced brain perfusion was detected and is accompanied by an ischemic metabolic profile with reduction of high-energy phosphates and elevated brain lactate. In addition, angiography supplies compelling evidence for major hemodynamics dysfunction. Actually, edema further worsens ischemia by compressing cerebral arteries, which subsequently leads to a collapse of the blood flow that ultimately represents the cause of death. These findings demonstrate the coexistence of inflammatory and ischemic lesions and prove the preponderant role of edema in the fatal outcome of experimental cerebral malaria. They improve our understanding of the pathogenesis of cerebral malaria and may provide the necessary noninvasive surrogate markers for quantitative monitoring of treatment.</jats:p>
収録刊行物
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- The Journal of Neuroscience
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The Journal of Neuroscience 25 (32), 7352-7358, 2005-08-10
Society for Neuroscience
